It can also lead to hypertension, elevated blood sugar, suppression of the body's natural steroids, and stretch marks, which may be permanent. Whitening creams with clobetasol propionate, such as Hyprogel, can make skin thin and easily bruised, with visible capillaries, and acne. It is also sold internationally, and does not require a prescription in some countries. Nonetheless, skin-whitening creams containing this ingredient can sometimes be found in beauty supply stores in New York City and on the internet. Food and Drug Administration has not approved it for that purpose, and sales without a prescription are illegal in the U.S. Ĭlobetasol propionate is used cosmetically for skin whitening, although this use is controversial. It is used as first-line treatment for both acute and chronic GVHD of the skin. It is also used to treat several auto-immune diseases including alopecia areata, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). Ĭlobetasol propionate is used for the treatment of various skin disorders including eczema, herpes labialis, psoriasis, and lichen sclerosus. In 2019, it was the 180th most commonly prescribed medication in the United States, with more than 3 million prescriptions. It is a US Class I (Europe: class IV) corticosteroid, making it one of the strongest available.Ĭlobetasol propionate was patented in 1968 and came into medical use in 1978. Clobetasol is believed to work by activating steroid receptors. Use in pregnancy and breastfeeding is of unclear safety. Serious side effects may include adrenal suppression, allergic reactions, cellulitis, and Cushing's syndrome. Ĭommon side effects include skin irritation, dry skin, redness, pimples, and telangiectasia. Use is not recommended in rosacea or perioral dermatitis. Use should be short term and only if other weaker corticosteroids are not effective. It is applied to the skin as a cream, ointment, or shampoo. Clobetasol propionate is a corticosteroid used to treat skin conditions such as eczema, contact dermatitis, seborrheic dermatitis, and psoriasis.
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